• Defining the multiple roles of autophagy in stroke has

  2024-06-17

  

  Defining the multiple roles of autophagy in stroke has been a rapidly evolving and exciting venue for translational research, with innovative products being applied from bench to bedside. Spanning pharmacological pathway manipulation and functional experimental validation, altered autophagy activati

• br Mechanisms of GPCR internalization Like for other types o

  2024-06-17

  

  Mechanisms of GPCR internalization Like for other types of receptors, prolonged agonist stimulation often leads to GPCR internalization, which can occur via different pathways ∗[2], [20], [21], [22], [23]. Of these pathways, clathrin-mediated NADP/NADPH Quantitation Colorimetric Kit sale (CME) i

• Mechanistically it was soon realized that

  2024-06-17

  

  Mechanistically, it was soon realized that in undead cells, Dronc promotes the activation of Jun-N-terminal kinase (JNK) signaling as the major inducer of AiP [25], [28] (Fig. 2B,C). However, it has been unknown for a long time how active Dronc promotes JNK signaling. Recently, it was reported that

• br Introduction Active oxygen radicals in the human

  2024-06-17

  

  Introduction Active oxygen radicals in the human body have a strong effect of inducing lipid peroxidation, which in turn induces oxidative imbalance and causes various diseases. Natural polysaccharides are substances with certain antioxidant activity. They are used as antioxidants and have advant

• It has been well established that shortly after systemic

  2024-06-17

  

  It has been well established that shortly after systemic inflammation, NADPH oxidase and iNOS activity were increased in the A 779 australia and lead to overproduction of reactive oxygen species (ROS) and NO [66]. Moreover, previous studies indicated that Ang II induced an increased level of NADPH

• With regard to participation of the S lipoxygenase

  2024-06-14

  

  With regard to participation of the 12S-lipoxygenase in diabetes mellitus, inconsistent results have been obtained. Earlier studies demonstrated that the leukocyte-type 12S-lipoxygenase is specifically expressed in pancreatic b-cells and is involved in regulating glucose-stimulated insulin secretion

• Despite extensive studies on the

  2024-06-14

  

  Despite extensive studies on the expression of T. pallidum-induced pro-inflammatory cytokines, very little is known about T. pallidum-mediated intracellular signaling pathway activation, that leads to cytokine expression in macrophages. A network of signaling molecules, transcription factors, epigen

• It could be hypothesized that the adiponectin system is regu

  2024-06-14

  

  It could be hypothesized that the adiponectin system is regulated by gonadal steroid hormones. The lowest concentrations of adiponectin, AdipoR1 and AdipoR2 proteins in the endometrium and myometrium during the mid-luteal and late-luteal phases suggest that progesterone suppresses the expression of

• br Hypoadiponectinemia in metabolic syndrome APN belongs str

  2024-06-14

  

  Hypoadiponectinemia in metabolic syndrome APN belongs structurally to the complement 1q family and is found at high concentrations (>0.01% of total protein) in the serum of healthy individuals [6]. Given the abundance of APN in plasma, it is assumed that alterations in plasma levels of APN might

• Adenosine is an endogenous nucleoside that plays pivotal rol

  2024-06-14

  

  Adenosine is an endogenous nucleoside that plays pivotal roles in different physiological and pathophysiological processes by triggering specific cell-surface receptors both in the ML347 synthesis and in the periphery. The adenosine receptors (ARs) are four different subtypes of G protein-coupled r

• br Effective therapeutic window of AR

  2024-06-14

  

  Effective therapeutic window of AR actions on ROP Retinal vasculature undergoes critical developmental changes postnatally: from P7 onward the superficial corticotropin releasing factor start sprouting vertically in retina to form first the deep then the intermediated vascular plexus in the retin

• Until now the molecular interactions of

  2024-06-14

  

  Until now, the molecular interactions of Tmod or Lmod with H-Ser-OH had been assessed in pyrene-actin polymerization assays [13], [23], [27], [28], [44], [45] or directly measured using non-denaturing polyacrylamide gel-electrophoresis (for Tmod isoforms only [23]), ITC (for Tmod1 and Lmod2) [43], [

• Our study like that of Zill et al included European

  2024-06-14

  

  Our study, like that of Zill et al. (2012) included European Caucasians, although their population was much smaller (n=162) and more heterogeneous (19–72years). Further, potential confounding or effect modification by other health, lifestyle or genetic factors was not considered. These differences m

• br Conclusions br Acknowledgments br Introduction

  2024-06-14

  

  Conclusions Acknowledgments Introduction To die or not to die – that is the question. Christian de Duve created the word “autophagy” in 1960’s for the first time (Klionsky et al., 2016). The word “autophagy” was derived from the Greek roots “auto” (self) and “phagy” (eating) and referred to

• Imatinib is a well known anticancer drug used in

  2024-06-14

  

  Imatinib is a well-known anticancer drug used in Chronic Myeloid Leukemia (CML) against the altered expression/activity of tyrosine kinase resulting from the fusion of BCR-ABL in leukemic blasts. It has been demonstrated that Imatinib can induce autophagy in BCR-ABL expressing Nicotine Difartrate (

14856 records 132/991 page Previous Next First page 上5页 131132133134135 下5页 Last page