• HPgV coinfection has been associated with reduced liver dise

  2022-03-18

  

  HPgV coinfection has been associated with reduced liver disease in HPgV/HCV/HIV triply infected patients (Barbosa Ade et al., 2009, Berzsenyi et al., 2007, Berzsenyi et al., 2009, Berzsenyi et al., 2011). It is possible that HCV NS3 protease inhibitors could inhibit HPgV replication diminishing its

• Flavin adenine dinucleotide disodium Phagocytosis was observ

  2022-03-18

  

  Phagocytosis was observed at 60 min after mixing macrophages with microbes (A). The phagocytosis ability (PA) and phagocytosis index (PI) values of the macrophages engulfing the bacteria measured in flow cytometer were shown in histograms (B). Statistical analyses revealed that both the PA and PI va

• br Lactate metabolism L Lactate

  2022-03-18

  

  Lactate metabolism L-Lactate is an intermediate metabolite in glucose metabolism. Glucose can be broken down to pyruvate, and pyruvate can be either further oxidized to acetyl-CoA and enter the TCA cycle, or reduced to L-lactate by lactate dehydrogenase (LDH). In turn, LDH can oxidize L-lactate t

• br Amino acids The role

  2022-03-18

  

  Amino acids: The role of leucine Amino GI 254023X metabolism plays a central role in brain physiology, as several amino acids serve as biosynthetic precursors for neurotransmitter synthesis [36]. In addition, the amino acids L-leucine and L-lysine may participate in ketogenesis. For these reason

• TCS PIM-1 1 br Conclusions br Conflicts of

  2022-03-18

  

  Conclusions Conflicts of Interest Introduction Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic multisystem illness of unconfirmed cause. ME/CFS has largely been diagnosed from Fukuda CFS criteria and/or the Canadian ME/CFS criteria. The Institute of Medicine in 2015

• 3230 To gain insights for further

  2022-03-18

  

  To gain insights for further improvement of the agonistic activity, we compared the structural features of the -carbamate piperidine moiety in with that of the spirocyclic moiety in –. Obviously, the substituent corresponding to an isopropyl group on the -carbamate in was lacking in the spirocycli

• br Materials and methods br Results br Discussion To

  2022-03-18

  

  Materials and methods Results Discussion To fulfill its role in tissue homeostasis, repair and immunoregulation, MSCs must be able to (i) renew themselves by cell division and proliferation, (ii) migrate to its target end-site in response to chemotaxis signals and (iii) undergo appropriate

• ARQ 197 br Materials and methods br Results br Discussion To

  2022-03-18

  

  Materials and methods Results Discussion To the best of our knowledge, the current study presented the first evidence that GPR40, also named FFAR1, played an essential role in bone formation and mediated ARQ 197 induced osteogenic effect via Wnt/β-catenin signaling. We found that dose–respo

• The regulation of casein expression during lactation is a

  2022-03-17

  

  The regulation of casein expression during lactation is a complex process involving a coordinated response at several levels. A variety of hormones are known to play roles in lactogenesis, such as prolactin (PRL), insulin, and hydrocortisone, and there is now increasing evidence that growth factors

• Gap junction intercellular communication GJIC facilitates

  2022-03-17

  

  Gap junction intercellular communication (GJIC) facilitates the exchange of ions, metabolites, Ca2+, inositol phosphates, and/or cyclic nucleotides of up to 1.8 kD in size between TAME through contact-dependent mechanisms [3,4]. Oocyte growth and development (as depicted in Fig. 1) depends, at least

• Ionotropic aminobutyric acid GABA receptors GABARs belong to

  2022-03-17

  

  Ionotropic γ-aminobutyric Dynasore (GABA) receptors (GABARs) belong to the Cys-loop ligand-gated ion channel (LGIC) superfamily and play an important role in the rapid inhibitory synaptic transmission in nervous systems of both vertebrate and invertebrate (Buckingham et al., 2005). Insect ionotropi

• D appears to be important for

  2022-03-17

  

  D83 appears to be important for receptor function as a mutation to an alanine produced a non-functional channel. Interestingly, maintaining the charge as in D83E produced only a small reduction in GABA sensitivity. Other mutations at this position which included residues capable of hydrogen bonding

• In addition to the type of food consumed also

  2022-03-17

  

  In addition to the type of food consumed, also the effect of calorie restriction (CR), i.e. an intermittent fasting and re-feeding cycles with concomitant fluctuations in the level of glucose and insulin, can affect the course of IBS through the modulation of the BA homeostasis. This type of nutriti

• We found that silymarin induced more improvement of renal fu

  2022-03-17

  

  We found that silymarin induced more improvement of renal functions compared to Rvs. Our results were in agreement with previous studies. The effect of silymarin has been tested in alloxan-induced diabetes mellitus models in rats. Alloxan produces reactive oxygen species which injure renal tissue. S

• The minimal segment of the

  2022-03-17

  

  The minimal segment of the SIM appears to be a core of arginase inhibitor residues, which frequently matches the consensus sequences ΨΨΨΨ, ΨxΨΨ, or ΨΨxΨ (where Ψ is V, I, or L and x is typically D, E, S, or T) [29,31,32]. In a subset of SIMs, this hydrophobic core is flanked by serine residues and

14501 records 440/967 page Previous Next First page 上5页 436437438439440 下5页 Last page