• As cardiovascular disease accounts for the majority of death

  2022-05-04

  

  As cardiovascular disease accounts for the majority of deaths in subjects with T2D, it is imperative that we better characterize the cardiovascular risks and benefits of the various therapies we prescribe to these individuals to control their glycemia. Indeed, the potential to identify subsets of di

• br Conflict of interest br Introduction Since its discovery

  2022-05-04

  

  Conflict of interest Introduction Since its discovery in 1958 [1]the Ca2+-dependent K+ efflux in human red blood Tranilast (RBC) (further referred to as the Gárdos effect) has been extensively studied (see 2, 3for review) and has been helpful in understanding the role of the Ca2+-activated K+

• Cx has been shown to

  2022-05-04

  

  Cx45 has been shown to be serine phosphorylated by CaMKII, CK1, PKA, and MAPK in HeLa Pam3CSK4 [77], [78]. Phosphorylation by PKA and MAPK were associated with decreased junctional conductance [78], suggesting that phosphorylation of Cx45 may influence conduction properties. Overall, the roles of b

• 350 The Notch cleavage efficiency of Aph aS

  2022-05-04

  

  The Notch-cleavage efficiency of Aph1aS containing complexes was lower than that of Aph1aL γ-secretases, especially in combination with PS2, suggesting that Aph1aS is a determinant of low Notch-cleavage specificity, considering that the different subcellular localization of PS1 and PS2 didn't affect

• In case where an extreme loop of up to

  2022-05-04

  

  In case where an extreme loop (of up to 45 nt) is allowed, as in G3 + E3 + XX, however, a G3+GQ loop maximum of 3 was adequate to reach high J-statistic. It continued to increase only up to 6 as the loop maximum. (Fig. 1A) Hence we suggest using a G3+GQ loop maximum between 3 and 6 where an extreme

• Channeling of SFA away from generation of toxic

  2022-05-04

  

  Channeling of SFA away from generation of toxic lipid metabolites such as ceramide, towards inert TG accumulation in response to cosupplementation with increased levels of MUFAs has previously been shown in many cell types including the pancreatic β-cells [37]. Our studies indicate that similar mech

• Apoptosis via Fas FasL system has been evidenced to play

  2022-04-29

  

  Apoptosis via Fas/FasL system has been evidenced to play a role in the pathogenesis of many diseases [26], [27], [28], [29], [30], [31], [32], [33], [34]. Along with these, Fas/FasL system has an important role in progressive renal disease and organ rejection in renal, cardiac and liver transplanta

• Over the years a number of studies

  2022-04-29

  

  Over the years, a number of studies have reported results concerning the behavior of the two endothelin receptor subtypes, ETA and ETB, that do not fit the classical model of two G protein-coupled receptors acting independently of one another. For example, in the rat anterior pituitary gland, both E

• fura 2 am This crosstalk may be responsible

  2022-04-29

  

  This crosstalk may be responsible for the beneficial effects of histamine H2 receptor inverse agonists on fura 2 am pathologies and may also explain unwanted effects of these drugs on other tissues. In this way, Allen et al. reported an anaphylactoid reaction following cessation of high-dose raniti

• Hypoxia HIF and Inflammation Cellular responses to hypoxia a

  2022-04-29

  

  Hypoxia, HIF, and Inflammation Cellular responses to hypoxia are essential for life and are now recognized to be dysregulated in a wide range of disease processes. The key players in these pathways are a family of transcription factors, the hypoxia-inducible factors (HIFs; see Glossary), as well as

• Bioinformatic analysis revealed a putative coiled coil

  2022-04-29

  

  Bioinformatic analysis revealed a putative coiled-coil SLD within CT229 which we show to be essential for intracellular replication and recruitment of Rab GTPases to the inclusion. Mutation of a single amino Senexin B residue in the SLD domain (CT229L120D) significantly reduced Rab binding and recr

• ANA 12 One of the mechanism of regulation of NO

  2022-04-29

  

  One of the mechanism of regulation of NO content in plant cells is it scavenging by GSH leading to formation of GSNO [59]. This reaction, depending on NO level and availability of glutatione in its reduced form, influences cellular redox potential by lowering GSH content and in consequence may impac

• br A selective inhibitor of mammalian histone

  2022-04-26

  

  A selective inhibitor of mammalian histone deacetylase, trichostatin A, reduces GnRH mRNA expression Epigenetic mechanisms controlling GnRH expression have been reported, and these mechanisms may be involved in the development and maturation of GnRH neurons in the brain (Gan et al., 2012, Kurian

• CTX0294885 The CO chemosensitivity of the LH PFA

  2022-04-26

  

  The CO2 chemosensitivity of the LH/PFA has been shown to be dependent on sleep-wake states (B.S. Deng et al., 2007; Dias et al., 2010, 2009; Li et al., 2013). In this context, it was demonstrated that focal acidification of the LH/PFA, by microdialysis of acidic artificial cerebrospinal fluid (aCSF)

• In this study our result

  2022-04-25

  

  In this study, our result suggests that exogenous GR agonist DEX and GR inhibitor RU486 can affect dopaminergic neurotransmitters in the brain. Pituitary adenylate cyclase-activating polypeptide (PACAP), an endogenous neuropeptide, can regulate the synthesis and release of catecholamine. McArthur et

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