• br Materials and methods br Results To

  2022-04-15

  

  Materials and methods Results To examine the time and organ specific effect of normal photoperiod and dark environment on the Kisspeptin 234 of different SlHXKs and on the enzyme activities, these parameters were determined in different leaf positions of tomato plants. Under control condition

• LJH685 The molecular mechanisms underlying spindle orientati

  2022-04-14

  

  The molecular mechanisms underlying spindle orientation are still largely unknown. Budding yeast has been used to study spindle positioning and asymmetric cell division. Indeed, after cytokinesis, daughter cells have different sizes. The cell division plane is established early in the cell cycle and

• We observed that the Toc G domain

  2022-04-14

  

  We observed that the Toc159G domain recognizes the N-terminal portion of the transit peptide of pSSU with a dissociation constant of 70 μM (Fig. 2; Table 1), while a tenfold higher KD was obtained for the phosphorylated C-terminal region. In turn, the homodimer of Toc34G recognizes the phosphorylate

• GSK is a critical component

  2022-04-14

  

  GSK-3 is a critical component of the Wnt signaling pathway. The Wnt/beta-catenin signal transduction pathway is important in normal growth and development and is also frequently dysregulated in cancer and other diseases. The Wnt/beta-catenin pathway is finely tuned by both positive and negative inte

• 8-Bromo-cGMP, sodium salt GPR belongs to the G protein coupl

  2022-04-14

  

  GPR84 belongs to the G protein-coupled receptor family, and it was first identified from human peripheral blood neutrophils [,]. GPR84 is now considered to be a member of receptor for medium chain fatty 8-Bromo-cGMP, sodium salt (MCFA) with carbon chain lengths of 9–14 []. GPR84 is mainly expressed

• br Introduction Marijuana remains the most widely used illeg

  2022-04-14

  

  Introduction Marijuana remains the most widely used illegal drug (Murray et al., 2007), and its validated targets include plasma membrane cannabinoid receptors, many of which are found in the central nervous system. The diverse physiological effects produced by marijuana and cannabinoid ligands s

• SGCs tightly ensheath the soma of DRG

  2022-04-14

  

  SGCs tightly ensheath the soma of DRG neurons (Costa and Moreira, 2015, Hanani, 2005, Takeda et al., 2009). Intimate associations between SGCs and neurons facilitate bidirectional regulation of SGC function and neuronal excitability. After nerve injury, neuronal hyperexcitability can result in SGC a

• br Introduction Verticillium dahliae Kleb

  2022-04-14

  

  Introduction Verticillium dahliae (Kleb.) is a soil-borne fungal pathogen that is able to infect hundreds of plant species, and causes vascular wilt disease [1], [2]. In nature, the infection of V. dahliae initiates from the germination of resting structures called microsclerotia [3]. The germina

• br Materials and methods br Results

  2022-04-14

  

  Materials and methods Results Discussion Although large-scale purification of homogeneous and functional membrane proteins is challenging, it is essential for biochemical, biophysical and structural characterization. This is particularly true for human P-gp, as its atomic structure has only

• The GlyR is pentameric with each subunit

  2022-04-14

  

  The GlyR is pentameric, with each subunit consisting of an extracellular ligand binding domain (LBD), four transmembrane (TM) segments, and a large intracellular loop between TM3 and TM4. Binding of neurotransmitter produces conformational changes that are rapidly transmitted to the membrane-spannin

• br Acknowledgements br Introduction Aminoacyl tRNA synthetas

  2022-04-14

  

  Acknowledgements Introduction Aminoacyl-tRNA synthetases catalyze the formation of an ester bond between an amino galunisertib and the 3′ end of a tRNA in a two-step reaction. First, the amino acid is activated and an enzyme-bound adenylate intermediate is formed. Then, the amino acid is trans

• Nuclear export of GK has been reported to be

  2022-04-14

  

  Nuclear export of GK has been reported to be dependent on a GK nuclear export signal (NES), mapped to residues 300–310 (Shiota et al., 1999). The assignment of a nuclear export signal common to both the liver and pancreatic GK isoform sequence suggests a possible reversible translocation of GK acros

• GLP and glucose dependent insulinotropic peptide GIP are gut

  2022-04-14

  

  GLP-1 and glucose-dependent insulinotropic peptide (GIP) are gut hormones secreted from intestinal L TIC10 mg and K cells, respectively. Together, these hormones account for the vast majority of the incretin effect, the enhanced postprandial insulin secretion observed in healthy adults (Dupre et al

• br Conflicts of interests br Acknowledgements We thank Drs T

  2022-04-14

  

  Conflicts of interests Acknowledgements We thank Drs. T. Tomita and T. Iwatsubo (Tokyo University, Tokyo, Japan) for anti-presenilin 1-CTF antiserum, Dr. A. Takashima (Gakushuin University, Tokyo, Japan) for anti-Pen-2 antiserum and the laboratory members for helpful comments and discussion. M

• The present data suggest that

  2022-04-13

  

  The present data suggest that the decrease of liver BAs was mainly due to the decrease of hepatic BAs synthesis because the BA synthetic enzymes Cyp7a1, Cyp7b1 and Cyp8b1 were markedly reduced. The increase may also be due to the increase of hepatic BAs efflux, because the liver BA efflux transporte

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