• Recently multiple receptor agonists have been developed to

  2021-12-28

  

  Recently, multiple receptor agonists have been developed to treat type II diabetes (Finan et al., 2013, Finan et al., 2015). We have tested novel dual GLP-1/GIP receptor agonists that showed good neuroprotective effects that are superior to single GLP-1 analogues (Cao et al., 2016, Jalewa et al., 20

• br The Farnesoid X receptor FXR identification and ligands T

  2021-12-28

  

  The Farnesoid X receptor (FXR): identification and ligands The Farnesoid X receptor (FXR) belongs to a family of proteins called Nuclear Receptors (NRs). NRs are a class of ligand-activated transcription factors, which transactivate networks of target genes, thereby mediating a wide range of phys

• Riboflavin mg While earlier reports on ferroptosis did not c

  2021-12-28

  

  While earlier reports on ferroptosis did not clarify mitochondrial damage and consequent death signaling in this paradigm of oxidative death, evidence from recent studies in neuronal systems strongly suggested a mechanistic link between enhanced lipid peroxide formation and loss of mitochondrial int

• The root of Danshen has been widely

  2021-12-28

  

  The root of (Danshen) has been widely used as traditional Chinese medicine for many years and shown to exhibit significant pharmacological activities for a variety of human diseases including cancers. Tanshinones, the major active components, belong to a group of an abietane-type diterpenes contain

• br Methods br Acknowledgements We are

  2021-12-28

  

  Methods Acknowledgements We are grateful to Eric Olson for providing Yap/Taz floxed mice, and to members of the Epstein lab for helpful comments and advice. This work was supported by NIH R01 HL118768, R35 HL140018, the Cotswold Foundation and the WW Smith Endowed Chair to J.A.E. The Hippo

• Given the role that activation of GC C

  2021-12-28

  

  Given the role that activation of GC-C has in stimulating fluid secretion in the intestine, attempts have been made to exploit this pathway to relieve symptoms of chronic constipation. Currently, an orally administered synthetic ST mimic, linaclotide [29], has been successfully shown to alleviate co

• Interestingly systemic circulating levels of NOx

  2021-12-28

  

  Interestingly, systemic circulating levels of NOx were not dramatically increased by treatment with isosorbide mononitrate or sodium nitrite at a dose which exerted beneficial effects on the progression of PH. In line with our results, Mathew et al. [13] demonstrated that the long-acting NO donor mo

• In this study we also investigated the role of GST

  2021-12-28

  

  In this study, we also investigated the role of GST GMX1778 in relation to ASD. In univariable analyses, where the role of each GST gene (i.e., GSTM1, GSTT1, GSTP1) was individually assessed, we did not observe any significant associations between the GST genotypes and ASD. In contrast, a previous

• Financial nonfinancial disclosures The authors have

  2021-12-28

  

  Financial/nonfinancial disclosures: The authors have reported to CHEST the following: M. J. A. has received investigator-initiated grants from Pfizer and Boehringer Ingelheim for unrelated research. None declared (X. D., S. C. D., G. B., N. T. W., J. L. P., J. H., B. E., A. J. L., J. A. B., C. S., C

• Studies with GSNOR knockout mice reported decreased CD cells

  2021-12-28

  

  Studies with GSNOR knockout mice reported decreased CD4+ Droxinostat and increased CD19+ cells (B-cell) in the blood [31] as well as demyelination, neurodegeneration, and neuropathic pain [29]. To understand the basis of these differences in immune function of GSNOR knockout mice and GSNO treated mi

• GSK can function in regulating insulin

  2021-12-28

  

  GSK-3 can function in regulating insulin signaling and glucose metabolism. Inactivation of GSK-3 activity results in dephosphorylation and activation of GS that leads to improved glucose tolerance. However, there are additional mechanisms that can lead to increases in GS activity and improve insulin

• Also in this work we investigated the correlated signaling p

  2021-12-28

  

  Also in this work, we investigated the correlated signaling pathways of GSK-3 inhibition in protecting bupivacaine-induced DRG neurotoxicity. Through western blot assay, we demonstrated that, SB216763 suppressed protein productions of p-GSK-3 α/β and Casp-3, but increased protein production of PKC,

• The structure and activity of GLUT has been

  2021-12-28

  

  The structure and activity of GLUT1 has been most intensively studied in erythrocytes, in which this transporter makes up 10–20% of membrane protein content. Carruthers has shown that, while GLUT1 can exist and transport glucose as monomers, dimers and tetramers, in erythrocytes GLUT1 exists predomi

• Nowadays there is no information if bifunctionality is an ex

  2021-12-28

  

  Nowadays, there is no information if bifunctionality is an exclusive trait of the order Methanococcales or if this characteristic is shared by other orders from archaea, like Methanosarcinales. These organisms are mainly methanogenic, and are not able to use exogenous hexoses as carbon source for ce

• The regulation of casein expression

  2021-12-28

  

  The regulation of casein expression during lactation is a complex process involving a coordinated response at several levels. A variety of hormones are known to play roles in lactogenesis, such as prolactin (PRL), insulin, and hydrocortisone, and there is now increasing evidence that growth factors,

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