• Conoidin A Cell swelling stimulates the release of certain a

  2019-08-17

  

  Cell swelling stimulates the release of certain amino acids, in particular the non-protein amino Conoidin A taurine, via a pathway which has the characteristics of a channel rather than a carrier [54], [69]. Indeed, on the basis of pharmacological inhibition, it was suggested that volume-activated

• br Acknowledgements Professor Olli A

  2019-08-17

  

  Acknowledgements Professor Olli A. Jänne is warmly thanked for support and for providing excellent research facilities. Professor Patrik Finne is acknowledged for his help with statistical analyses. Drs Ronald Evans, Vincent Giguère, Jorma Palvimo, Malcolm Parker, and Anastasia Kralli are acknowl

• TKI discontinuation studies demonstrate that a portion of TK

  2019-08-17

  

  TKI discontinuation studies demonstrate that a portion of TKI-treated CML patients remain in remission for up to 3 years, although long-term risk assessment is still necessary (Bansal and Radich, 2016). The majority of CML patients depend on lifetime TKI treatment, and substantial efforts have been

• Muscle Ring Fingers MuRFs comprising TRIM MuRF TRIM MuRF

  2019-08-17

  

  Muscle Ring Fingers (MuRFs) comprising TRIM63 (MuRF1), TRIM55 (MuRF2) and TRIM54 (MuRF3) are the most studied TRIMs in the heart. However, with increasing knowledge of E3 ligases and recent advancements in the field, many other TRIMs such as TRIM8, TRIM21, TRIM24, TRIM32, TRIM45, TRIM69 and TRIM72 w

• A surprising second functional effect was found in

  2019-08-17

  

  A surprising second functional effect was found in culture experiments. Inclusion of LTD4 reduced the frequency of Fas receptor (CD95) expression. Once again, this effect, although modest, was reversed by a cysLT1 receptor antagonist. The biologic significance of this effect or its mechanism remaine

• br Chagas disease and HAT drug R D Drug

  2019-08-17

  

  Chagas disease and HAT drug R&D Drug R&D for Chagas disease and HAT has historically relied on serendipitous findings achieved using low-technology approaches. The absence of biotechnology tools associated and the very limited understanding of the biomolecular processes of the parasites are amon

• Carnitine acetyltransferase CrAT transesterifies short chain

  2019-08-17

  

  Carnitine acetyltransferase (CrAT) transesterifies short-chain acyl-CoAs, and is located both in mitochondria and peroxisomes. In yeasts and mammals this protein is the product of a single gene [20,21] and the sorting to different organelles is evolutionary conserved, although the mechanism of diffe

• The aniline R group was extensively explored and a large

  2019-08-16

  

  The aniline R2 group was extensively explored and a large variety of substitution was tolerated at several positions on the aryl ring (). Notably, substitution at the 3-position often gave increased potency. Increasing lipophilic bulk at this position gave increasing potency within an ether series (

• In vitro work by us and others

  2019-08-16

  

  In vitro work by us and others revealed that high affinity interaction with collagen requires dimerization and/or pre-oligomerization of DDR1 (Agarwal et al., 2007, Abdulhussein et al., 2008, Leitinger, 2003). It has also been reported that a significant percentage of the DDR1 population forms ligan

• We next examined the effects of

  2019-08-16

  

  We next examined the effects of substituents around the carboxylic Etoposide in moiety on CRTH2 binding (Table 4). The carboxylic acid moiety shared by the representative CRTH2 antagonists and is essential for the CRTH2 activity. Germinal dimethylation of the methylene moiety next to the carboxylic

• Crystal structures of various CRM

  2019-08-16

  

  Crystal structures of various CRM1 complexes have provided insight into molecular details of the interactions between CRM1 and its interaction partners during the transport cycle. CRM1 cooperatively binds RanGTP and cargo in the nucleus (Paraskeva et al., 1999). In this ternary complex, RanGTP is lo

• Animal studies investigating the role of D

  2019-08-16

  

  Animal studies investigating the role of D1 dopamine receptors in the PFC have focused on delayed response tasks, which require online maintenance of a previously presented stimulus. Striatal dopamine is thought to be important for flexibility and updating goal representations when new information i

• EP is the major receptor to mediate

  2019-08-16

  

  EP4 is the major receptor to mediate PGE2-induced inflammatory pain. EP4 is upregulated by 5,8,11-Eicosatriynoic Acid in DRG neurons [16]. Intrathecal injection of the EP4 agonist produced pain responses [25]. Either systemic or local injection of EP4 antagonists relieves inflammatory pain [3], [16

• br Methods An ongoing prospective

  2019-08-16

  

  Methods An ongoing prospective study at the Princess Margaret Cancer Centre is enrolling consenting patients with stage IV EGFRm NSCLC for longitudinal blood collection. Patients may enrol at any point in their treatment. In this study, we performed a cross-sectional analysis of 72 patient liquid

• Calcium Colorimetric Assay Kit msds Accordingly we prepared

  2019-08-16

  

  Accordingly, we prepared three compounds (, , and ) as shown in . Condensation of commercially available Calcium Colorimetric Assay Kit msds with glycine methyl ester gave amide . A Friedel–Crafts reaction between compound and 4-methyl valeryl chloride in the presence of aluminum chloride mainly pro

14809 records 968/988 page Previous Next First page 上5页 966967968969970 下5页 Last page